Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing
This study introduces the groundbreaking synergistic influence of plasma and ion-exchange treatment (P-IET), conducted under varying conditions at temperatures of 450 °C and 500 °C for 2, 12, and 24 h, preceded by a few seconds of pre-plasma treatment using a mixed air-argon gas approach. P-IET is a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Applied Surface Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666523925000686 |
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| author | Ahmed Gamal Abd-Elsatar Hamada Elsayed Onat Basak Kamalan Mosas Aleksandra Nowicka Hana Kaňková Akansha Mehta Jozef Rahel Jozef Kraxner Dušan Galusek Enrico Bernardo |
| author_facet | Ahmed Gamal Abd-Elsatar Hamada Elsayed Onat Basak Kamalan Mosas Aleksandra Nowicka Hana Kaňková Akansha Mehta Jozef Rahel Jozef Kraxner Dušan Galusek Enrico Bernardo |
| author_sort | Ahmed Gamal Abd-Elsatar |
| collection | DOAJ |
| description | This study introduces the groundbreaking synergistic influence of plasma and ion-exchange treatment (P-IET), conducted under varying conditions at temperatures of 450 °C and 500 °C for 2, 12, and 24 h, preceded by a few seconds of pre-plasma treatment using a mixed air-argon gas approach. P-IET is a cost-effective, innovative, long-lasting, and industrially scalable process designed to improve the performance of Type I borosilicate glass across various pharmaceutical packaging forms and structures. This treatment produces a durable hydrophilic surface, as confirmed by FTIR analysis, which shows a broad and intense OH group peak at ∼3350 cm⁻¹, along with significant structural changes demonstrating enhanced water-attractive properties. Furthermore, P-IET significantly lowers water contact angles on the glass's inner surface, amplifying its hydrophilicity. These improvements are crucial for water-based drug formulations, facilitating efficient and waste-free drug delivery by enabling complete withdrawal and precise dosing—critical features and requirements for contemporary and modern pharmaceutical applications. This level of performance is crucial for ensuring safety and reducing waste associated with expensive and highly sensitive medications, including cytotoxic therapies and anticancer treatments.Beyond hydrophilicity, P-IET also significantly enhances the mechanical strength of glass by generating a robust compressive layer, hence doubling its resistance to crushing loads by 2124 ± 21 N (e.g., at 500 °C for 24 h) compared to untreated standard vials available on the market today, which have a resistance 1157 ± 91 N. Moreover, P-IET sterilizes the glass surface by removing biological contaminants, microorganisms, and organic residues and improves chemical durability by reducing Na and K ion leach-out, thus assuring long-term chemical stability under various pH conditions. Notably, these are achieved without changing the colour or transparency of the glass vials with preserving their aesthetic or functional integrities. The proposed transformative technology addresses critical challenges in pharmaceutical packaging by introducing a greener, safer, and highly effective solution. P-IET enables the complete withdrawal of medications with precise dosing and boasts exceptional mechanical and chemical resistance. This innovation sets new standards and benchmarks for Type I borosilicate glass while promoting the development of novel drug delivery systems distinguished by their unique reliability and sustainability. |
| format | Article |
| id | doaj-art-53f2f4a3b8fb441ea8acd91dc6108a0f |
| institution | Kabale University |
| issn | 2666-5239 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Surface Science Advances |
| spelling | doaj-art-53f2f4a3b8fb441ea8acd91dc6108a0f2025-08-20T03:26:38ZengElsevierApplied Surface Science Advances2666-52392025-06-012710076010.1016/j.apsadv.2025.100760Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosingAhmed Gamal Abd-Elsatar0Hamada Elsayed1Onat Basak2Kamalan Mosas3Aleksandra Nowicka4Hana Kaňková5Akansha Mehta6Jozef Rahel7Jozef Kraxner8Dušan Galusek9Enrico Bernardo10FunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, Slovakia; Department of Industrial Engineering, University of Padova, Padova, Italy; Department of Ceramics, National Research Centre, Cairo 12622, Egypt; Corresponding author at: FunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, Slovakia.Department of Industrial Engineering, University of Padova, Padova, ItalyFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaDepartment of Wood Science and Technology, Mendel University in Brno, Brno 613 00, Czech RepublicFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, SlovakiaFunGlass, Alexander Dubček University of Trenčín, Trenčín 911 50, Slovakia; Joint Glass Centre of the IIC SAS, TnUAD and FChFT STU, Trenčín 911 50, SlovakiaDepartment of Industrial Engineering, University of Padova, Padova, ItalyThis study introduces the groundbreaking synergistic influence of plasma and ion-exchange treatment (P-IET), conducted under varying conditions at temperatures of 450 °C and 500 °C for 2, 12, and 24 h, preceded by a few seconds of pre-plasma treatment using a mixed air-argon gas approach. P-IET is a cost-effective, innovative, long-lasting, and industrially scalable process designed to improve the performance of Type I borosilicate glass across various pharmaceutical packaging forms and structures. This treatment produces a durable hydrophilic surface, as confirmed by FTIR analysis, which shows a broad and intense OH group peak at ∼3350 cm⁻¹, along with significant structural changes demonstrating enhanced water-attractive properties. Furthermore, P-IET significantly lowers water contact angles on the glass's inner surface, amplifying its hydrophilicity. These improvements are crucial for water-based drug formulations, facilitating efficient and waste-free drug delivery by enabling complete withdrawal and precise dosing—critical features and requirements for contemporary and modern pharmaceutical applications. This level of performance is crucial for ensuring safety and reducing waste associated with expensive and highly sensitive medications, including cytotoxic therapies and anticancer treatments.Beyond hydrophilicity, P-IET also significantly enhances the mechanical strength of glass by generating a robust compressive layer, hence doubling its resistance to crushing loads by 2124 ± 21 N (e.g., at 500 °C for 24 h) compared to untreated standard vials available on the market today, which have a resistance 1157 ± 91 N. Moreover, P-IET sterilizes the glass surface by removing biological contaminants, microorganisms, and organic residues and improves chemical durability by reducing Na and K ion leach-out, thus assuring long-term chemical stability under various pH conditions. Notably, these are achieved without changing the colour or transparency of the glass vials with preserving their aesthetic or functional integrities. The proposed transformative technology addresses critical challenges in pharmaceutical packaging by introducing a greener, safer, and highly effective solution. P-IET enables the complete withdrawal of medications with precise dosing and boasts exceptional mechanical and chemical resistance. This innovation sets new standards and benchmarks for Type I borosilicate glass while promoting the development of novel drug delivery systems distinguished by their unique reliability and sustainability.http://www.sciencedirect.com/science/article/pii/S2666523925000686Borosilicate containersPlasma-ion exchange treatmentHydrophilicity enhancementMechanical strengthPharmaceutical packagingChemical durability |
| spellingShingle | Ahmed Gamal Abd-Elsatar Hamada Elsayed Onat Basak Kamalan Mosas Aleksandra Nowicka Hana Kaňková Akansha Mehta Jozef Rahel Jozef Kraxner Dušan Galusek Enrico Bernardo Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing Applied Surface Science Advances Borosilicate containers Plasma-ion exchange treatment Hydrophilicity enhancement Mechanical strength Pharmaceutical packaging Chemical durability |
| title | Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing |
| title_full | Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing |
| title_fullStr | Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing |
| title_full_unstemmed | Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing |
| title_short | Greener, safer, and stronger: plasma ion-exchanged pharmaceutical glass vials for precision drug delivery dosing |
| title_sort | greener safer and stronger plasma ion exchanged pharmaceutical glass vials for precision drug delivery dosing |
| topic | Borosilicate containers Plasma-ion exchange treatment Hydrophilicity enhancement Mechanical strength Pharmaceutical packaging Chemical durability |
| url | http://www.sciencedirect.com/science/article/pii/S2666523925000686 |
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