Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis
Introduction: Mean platelet volume (MPV) has been shown to reflect the inflammatory burden in different inflammatory and autoimmune diseases. Our objective was to analyze the MPV in patients with tuberculous (TBM) and bacterial meningitis (BM). Methodology: The demographic and clinical data of 73 c...
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The Journal of Infection in Developing Countries
2017-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/7478 |
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| author | Carlos Rodrigo Camara-Lemarroy Guillermo Delgado-Garcia Juan Gilberto De la Cruz-Gonzalez Hector Jorge Villareal-Velazquez Fernando Gongora-Rivera |
| author_facet | Carlos Rodrigo Camara-Lemarroy Guillermo Delgado-Garcia Juan Gilberto De la Cruz-Gonzalez Hector Jorge Villareal-Velazquez Fernando Gongora-Rivera |
| author_sort | Carlos Rodrigo Camara-Lemarroy |
| collection | DOAJ |
| description | Introduction: Mean platelet volume (MPV) has been shown to reflect the inflammatory burden in different inflammatory and autoimmune diseases. Our objective was to analyze the MPV in patients with tuberculous (TBM) and bacterial meningitis (BM).
Methodology: The demographic and clinical data of 73 consecutive patients that presented with either BM (n = 35) or TBM (n = 38) were retrospectively analyzed, as well as that of 28 age- and sex-matched controls.
Results: MPV was 8.78 ± 1.58 fL in patients with BM and 6.42 ± 1.39 fL in the TBM group (p < 0.05). In the control group, MPV was 7.4 ± 0.66 fL, significantly higher and lower when compared with TBM and BM, respectively. MPV was significantly associated with diagnosis (adjusted OR: 5.15, 95% CI: 1.090–23.7; p = 0.03). With the optimal cut-off value of 7.62 fL, MPV had 82% sensibility and 78% specificity for the differential diagnosis of TBM versus BM. Lower platelet counts, higher serum creatinine, higher white blood cell counts, and higher blood-cerebrospinal fluid glucose ratio were also predictive of BM.
Conclusions: Platelet counts were lower and MPV was higher in patients with BM compared to patients with TBM. Platelet indices, available in routine bloodwork, could be useful in the early differential diagnosis of these entities.
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| format | Article |
| id | doaj-art-50bd0d45c6a242518ca29d4afe935a5a |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-50bd0d45c6a242518ca29d4afe935a5a2025-08-20T02:57:21ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802017-02-01110210.3855/jidc.7478Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitisCarlos Rodrigo Camara-Lemarroy0Guillermo Delgado-Garcia1Juan Gilberto De la Cruz-Gonzalez2Hector Jorge Villareal-Velazquez3Fernando Gongora-Rivera4University Hospital “Dr. Jose E. González”, Autonomous University Of Nuevo Leon, Monterrey, Nuevo Leon, MexicoUniversity Hospital “Dr. Jose E. González”, Autonomous University Of Nuevo Leon, Monterrey, Nuevo Leon, MexicoUniversity Hospital “Dr. Jose E. González”, Autonomous University Of Nuevo Leon, Monterrey, Nuevo Leon, MexicoUniversity Hospital “Dr. Jose E. González”, Autonomous University Of Nuevo Leon, Monterrey, Nuevo Leon, MexicoUniversity Hospital “Dr. Jose E. González”, Autonomous University Of Nuevo Leon, Monterrey, Nuevo Leon, MexicoIntroduction: Mean platelet volume (MPV) has been shown to reflect the inflammatory burden in different inflammatory and autoimmune diseases. Our objective was to analyze the MPV in patients with tuberculous (TBM) and bacterial meningitis (BM). Methodology: The demographic and clinical data of 73 consecutive patients that presented with either BM (n = 35) or TBM (n = 38) were retrospectively analyzed, as well as that of 28 age- and sex-matched controls. Results: MPV was 8.78 ± 1.58 fL in patients with BM and 6.42 ± 1.39 fL in the TBM group (p < 0.05). In the control group, MPV was 7.4 ± 0.66 fL, significantly higher and lower when compared with TBM and BM, respectively. MPV was significantly associated with diagnosis (adjusted OR: 5.15, 95% CI: 1.090–23.7; p = 0.03). With the optimal cut-off value of 7.62 fL, MPV had 82% sensibility and 78% specificity for the differential diagnosis of TBM versus BM. Lower platelet counts, higher serum creatinine, higher white blood cell counts, and higher blood-cerebrospinal fluid glucose ratio were also predictive of BM. Conclusions: Platelet counts were lower and MPV was higher in patients with BM compared to patients with TBM. Platelet indices, available in routine bloodwork, could be useful in the early differential diagnosis of these entities. https://jidc.org/index.php/journal/article/view/7478meningitismean platelet volumeinflammationplateletsthrombocytopenia |
| spellingShingle | Carlos Rodrigo Camara-Lemarroy Guillermo Delgado-Garcia Juan Gilberto De la Cruz-Gonzalez Hector Jorge Villareal-Velazquez Fernando Gongora-Rivera Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis Journal of Infection in Developing Countries meningitis mean platelet volume inflammation platelets thrombocytopenia |
| title | Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| title_full | Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| title_fullStr | Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| title_full_unstemmed | Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| title_short | Mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| title_sort | mean platelet volume in the differential diagnosis of tuberculous and bacterial meningitis |
| topic | meningitis mean platelet volume inflammation platelets thrombocytopenia |
| url | https://jidc.org/index.php/journal/article/view/7478 |
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