Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome
BackgroundResearch on the association between blood glucose-related biomarkers and mortality has gained increasing attention. However, the association of hemoglobin glycation index (HGI) with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome has never been investiga...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1447184/full |
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| author | Leiyong Zhao Chengjun Li Hequn Lv Chunli Zeng Yongjun Peng |
| author_facet | Leiyong Zhao Chengjun Li Hequn Lv Chunli Zeng Yongjun Peng |
| author_sort | Leiyong Zhao |
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| description | BackgroundResearch on the association between blood glucose-related biomarkers and mortality has gained increasing attention. However, the association of hemoglobin glycation index (HGI) with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome has never been investigated. The objective of this study was to examine the association through a cohort study of the American population.MethodsIn this study, 8,267 participants were included. We utilized multivariable Cox regression analyses to explore the relationship between HGI and outcomes. The dose-response relationship between HGI and mortality was explored with restricted cubic splines. Recursive algorithms and segmented linear regression models were used to calculate the inflection points and assess the effect relationships before and after the inflection points.ResultsIn the model adjusting for all covariates, our analysis did not reveal a statistically significant association between HGI and mortality. Intriguingly, subsequent explorations of non-linear relationships unearthed a U-shaped correlation between HGI and both all-cause mortality and cardio-cerebrovascular mortality among American adults with metabolic syndrome. Before and after the inflection point, the HRs (95%CIs) for the association between HGI and all-cause mortality were 0.72 (0.63, 0.82) and 1.30 (1.17, 1.44), respectively. For cardio-cerebrovascular mortality, similar opposite relationships were found. The metabolic syndrome population with HGI levels at T2 had a lower rate of mortality.ConclusionThis cohort study of the American metabolic syndrome population highlighted a U-shaped association of HGI with all-cause and cardio-cerebrovascular mortality. |
| format | Article |
| id | doaj-art-4e42130b35334b24916cbb2067741642 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-4e42130b35334b24916cbb20677416422024-11-29T04:30:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-11-011510.3389/fendo.2024.14471841447184Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndromeLeiyong Zhao0Chengjun Li1Hequn Lv2Chunli Zeng3Yongjun Peng4Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Huangdao District Hospital of Traditional Chinese Medicine, Qingdao, ChinaDepartment of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaBackgroundResearch on the association between blood glucose-related biomarkers and mortality has gained increasing attention. However, the association of hemoglobin glycation index (HGI) with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome has never been investigated. The objective of this study was to examine the association through a cohort study of the American population.MethodsIn this study, 8,267 participants were included. We utilized multivariable Cox regression analyses to explore the relationship between HGI and outcomes. The dose-response relationship between HGI and mortality was explored with restricted cubic splines. Recursive algorithms and segmented linear regression models were used to calculate the inflection points and assess the effect relationships before and after the inflection points.ResultsIn the model adjusting for all covariates, our analysis did not reveal a statistically significant association between HGI and mortality. Intriguingly, subsequent explorations of non-linear relationships unearthed a U-shaped correlation between HGI and both all-cause mortality and cardio-cerebrovascular mortality among American adults with metabolic syndrome. Before and after the inflection point, the HRs (95%CIs) for the association between HGI and all-cause mortality were 0.72 (0.63, 0.82) and 1.30 (1.17, 1.44), respectively. For cardio-cerebrovascular mortality, similar opposite relationships were found. The metabolic syndrome population with HGI levels at T2 had a lower rate of mortality.ConclusionThis cohort study of the American metabolic syndrome population highlighted a U-shaped association of HGI with all-cause and cardio-cerebrovascular mortality.https://www.frontiersin.org/articles/10.3389/fendo.2024.1447184/fullhemoglobin glycation indexall-cause mortalitycardio-cerebrovascular mortalitycohort studymetabolic syndrome |
| spellingShingle | Leiyong Zhao Chengjun Li Hequn Lv Chunli Zeng Yongjun Peng Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome Frontiers in Endocrinology hemoglobin glycation index all-cause mortality cardio-cerebrovascular mortality cohort study metabolic syndrome |
| title | Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome |
| title_full | Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome |
| title_fullStr | Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome |
| title_full_unstemmed | Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome |
| title_short | Association of hemoglobin glycation index with all-cause and cardio-cerebrovascular mortality among people with metabolic syndrome |
| title_sort | association of hemoglobin glycation index with all cause and cardio cerebrovascular mortality among people with metabolic syndrome |
| topic | hemoglobin glycation index all-cause mortality cardio-cerebrovascular mortality cohort study metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1447184/full |
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