Cathodic Stripping Voltammetric Determination of Dimenhydrinate
Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hangi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
An-Najah National University
2014-09-01
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| Series: | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
| Subjects: | |
| Online Access: | https://journals.najah.edu/media/journals/full_texts/3_f6as6hm.pdf |
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| Summary: | Dimenhydrinate (DMH) is a derivative of theophylline (diphenhydramine salt of 8-chloro theophylline). Both dimenhydrinate and theophylline are used as antihistamines in treatment of asthma, in addition to other important pharmaceutical uses. A three-electrode voltammetric system was used, with hanging mercury drop electrode (HMDE) as working electrode. A reduction peak of DMH at -0.2 to -0.3 V in acetate buffer, pH about 4.0 is obtained. The peak height is increased largely (tripled) in presence of Cu2+, due to the formation of DMH-Cu (I) complex. The detection limit is as low as 5x10-9 M DMH. Application of the analysis of two drugs containing dimenhydrinate was carried out, where a coefficient of variation of about 3% was obtained. |
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| ISSN: | 1727-2114 2311-8865 |