Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-function variants in the zinc efflux transpo...

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Bibliographic Details
Main Authors:	Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher Van Hout, Manuel AR Ferreira, Bin Ye, Alexander Li, Susannah Brydges, Vinayagam Arunachalam, Anthony Marcketta, Adam E Locke, Jonas Bovijn, Niek Verweij, Tanima De, Luca Lotta, Lyndon Mitnaul, Michelle LeBlanc, Regeneron Genetics Center, David J Carey, Olle Melander, Alan Shuldiner, Katia Karalis, Aris N Economides, Harikiran Nistala, DiscovEHR collaboration
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-12-01
Series:	eLife
Subjects:	Type II diabetes NAFLD zinc transporter
Online Access:	https://elifesciences.org/articles/90419
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Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

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