Antitumor effect of a new human epidermal growth factor receptor inhibitor

Antitumor effect of a new human epidermal growth factor receptor inhibitor

Purpose of the study. Preclinical study in experiment of antitumor efficacy of a new substance synthesized on the basis of pyrimidin-4-one derivative.Materials and methods. The sodium salt of 4-{2-[2-[2-(4-hydroxy-3-methoxyphenyl)-vinyl]-6-ethyl-4-oxo-5-phenyl-4H-pyrimidin-1-yl}-benzsulfamide, a new...

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Main Authors: O. I. Kit, I. P. Kodonidi, E. M. Frantsiyants, I. V. Kaplieva, A. A. Glushko, L. K. Trepitaki, E. I. Surikova, V. A. Bandovkina, Yu. A. Pogorelova, I. V. Neskubina, O. V. Bykadorova, E. V. Serdyukova
Format: Article
Language:Russian
Published: QUASAR, LLC 2024-09-01
Series:Исследования и практика в медицине
Subjects:
novel pyrimidin-4-one derivative-based egfr inhibitor
b16/f10 melanoma
c57bl6 mice
tumor growth inhibition index
sex-specific antitumor efficacy
preclinical studies
Online Access:https://www.rpmj.ru/rpmj/article/view/1007
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https://www.rpmj.ru/rpmj/article/view/1007

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