Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma

Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers demanding better and more effective therapies. BARD1 or BRCA1-Associated -Ring Domain-1 plays a pivotal role in homologous recombination repair (HRR). However, its function and the underlying molecular mechanisms in PDAC ar...

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Bibliographic Details
Main Authors: Sohum Patel, Eleanor Jenkins, Rutuj P Kusurkar, Sherry Lee, Wei Jiang, Avinoam Nevler, Matthew McCoy, Michael J Pishvaian, Rosalie C Sears, Jonathan R Brody, Charles J Yeo, Aditi Jain
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Pancreatic ductal adenocarcinoma
BARD1
PARP inhibitor
DNA damage
c-Myc
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000314
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