Synthesis, physical and chemical properties of esters of 2-((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)ethanoic and 3-(((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)methyl)benzoic acids

Synthesis, physical and chemical properties of esters of 2-((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)ethanoic and 3-(((5-(hydroxy(phenyl)methyl)-4-R-1,2,4-triazole-3-yl)thio)methyl)benzoic acids

The wide use of 1,2,4-triazole derivatives in medical practice is primarily explained by two most important properties: high biological activity and low toxicity. It is difficult to overestimate the contribution to medical practice, which such medicines as posaconazole and letrozole have made. Many...

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Bibliographic Details
Main Authors: А. M. Rud, A. G. Kaplaushenko, Yu. M. Kucheryavyi, Fadi Al Zedan
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2017-12-01
Series:Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:
4-triazole
synthesis
chemical properties
HPLC-MS
Online Access:http://pharmed.zsmu.edu.ua/article/view/113258/110365
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