The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells

The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells

Abstract CENP-F is a large protein acting in fundamental cell cycle processes, including nuclear envelope breakdown, mitotic microtubule function and chromosome segregation. These activities are mediated by specific CENP-F protein elements that interact with microtubules, motor proteins, centrosomes...

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Main Authors: Ludovica Altieri, Michela Damizia, Paola Rovella, Vincenzo Costanzo, Morena Mancini, Patrizio Di Micco, Matteo Marzi, Daniela Trisciuoglio, Veronica Morea, Patrizia Lavia
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
CENP-F
Importin beta
Microtubules
Mitotic spindle poles
Kinetochores
Protein stability
Online Access:https://doi.org/10.1038/s41598-025-96504-7
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