Preferential allosteric modulation of Otop1 channels by small molecule compounds

Preferential allosteric modulation of Otop1 channels by small molecule compounds

Abstract The Otopetrin (Otop) proteins, comprising Otop1-3, are proton-gated proton channels with key biological functions. Otop1 acts as a receptor for sour and ammonium salt tastes in mammals, but its gating mechanisms and pharmacology remain poorly understood. Here, we report the functional chara...

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Bibliographic Details
Main Authors: Xiangjin Kong, Jie Sun, Hanhan Zhang, Yuan Yin, Xinyao Liang, Yan Chen, Guoqing Luo, Huixin Xia, Youjun Wang, Zhonghua Liu, Cheng Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07775-9
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