Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model

Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model

Abstract Background In non-insulin-dependent, type 2, diabetes mellitus (T2D), glucose metabolism is compromised, and the heart loses its metabolic flexibility. The Zucker Diabetic Fatty rat (ZDF) model, which replicates the pathophysiology of T2D in patients, shows that as T2D progresses so does he...

Full description

Saved in:
Bibliographic Details
Main Authors: Etienne Croteau, Gabriel Richard, Patrick Prud’Homme, Etienne Rousseau, Stephen C. Cunnane, Véronique Dumulon-Perreault, Otman Sarrhini, Serge Phoenix, Sébastien Tremblay, Brigitte Guérin, Roger Lecomte
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:EJNMMI Research
Subjects:
Positron emission tomography
Ketone bodies
Acetoacetate
Beta-hydroxybutyrate
Myocardial blood flow
Type II diabetes
Online Access:https://doi.org/10.1186/s13550-025-01215-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13550-025-01215-9

Similar Items