Lipids as the link between central obesity and diabetes: perspectives from mediation analysis
Abstract Background Central obesity is a well-recognized risk factor for diabetes, yet the potential role of lipids in the diabetes risk associated with central obesity remains unclear. This study aimed to explore the possible mediating role of 11 lipid parameters [high-density lipoprotein cholester...
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BMC
2024-10-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01764-5 |
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| author | Song Lu Maobin Kuang Jiajun Qiu Wenjuan Li Min Zhang Guotai Sheng Yang Zou Xiaoping Peng |
| author_facet | Song Lu Maobin Kuang Jiajun Qiu Wenjuan Li Min Zhang Guotai Sheng Yang Zou Xiaoping Peng |
| author_sort | Song Lu |
| collection | DOAJ |
| description | Abstract Background Central obesity is a well-recognized risk factor for diabetes, yet the potential role of lipids in the diabetes risk associated with central obesity remains unclear. This study aimed to explore the possible mediating role of 11 lipid parameters [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), non-high-density lipoprotein cholesterol (Non-HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), remnant cholesterol (RC), and ratios of Non-HDL-C/HDL-C, RC/HDL-C, LDL/HDL-C, TG/HDL-C, TC/HDL-C] in the association of central obesity with diabetes risk. Methods We utilized data from 15,453 participants in the NAGALA longitudinal cohort to assess the association of baseline central obesity indicators [waist-height ratio (WHtR), waist circumference (WC)] and the 11 lipid parameters with diabetes risk. Mediation analysis models were constructed to explore the mediating role of lipid parameters in the association of WC/WHtR with diabetes. Results Confirmatory associative analysis using multivariable Cox regression showed that, except for Non-HDL-C, TC and LD-C, the remaining eight lipid parameters were significantly associated with WC/WHtR and diabetes risk. Mediation analysis indicated that TG, RC, HDL-C, and lipid ratios such as Non-HDL-C/HDL-C ratio, RC/HDL-C ratio, TG/HDL-C ratio, TC/HDL-C ratio and LDL/HDL-C ratio are potential lipids affecting the diabetes risk related to central obesity. Among these, the RC/HDL-C ratio seemed to contribute the most in the WC/WHtR-related diabetes risk association, with a mediation percentage of about 37%. Additionally, lipid ratio parameters appeared to play a more mediating role in the association of central obesity-related diabetes risk than individual lipids. Conclusions In central obesity-related diabetes risk, most lipids, especially lipid ratio parameters, play a significant mediating role. Given these findings, we advocate for increased efforts in multifactorial risk monitoring and joint management of diabetes. The evaluation of lipids, particularly lipid ratio parameters, may be holds substantial value in the prevention and management of diabetes risk under close monitoring of central obesity. |
| format | Article |
| id | doaj-art-423d6f0b68fa4b8db045bfd8b0fffd84 |
| institution | OA Journals |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-423d6f0b68fa4b8db045bfd8b0fffd842025-08-20T02:18:28ZengBMCBMC Endocrine Disorders1472-68232024-10-0124111510.1186/s12902-024-01764-5Lipids as the link between central obesity and diabetes: perspectives from mediation analysisSong Lu0Maobin Kuang1Jiajun Qiu2Wenjuan Li3Min Zhang4Guotai Sheng5Yang Zou6Xiaoping Peng7Department of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang UniversityDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang UniversityState Key Laboratory of Food Science and Resources, Nanchang UniversityDepartment of Cardiology, The First Affiliated Hospital of Nanchang UniversityJiangxi Provincial Geriatric Hospital, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical CollegeDepartment of Cardiology, The First Affiliated Hospital of Nanchang UniversityAbstract Background Central obesity is a well-recognized risk factor for diabetes, yet the potential role of lipids in the diabetes risk associated with central obesity remains unclear. This study aimed to explore the possible mediating role of 11 lipid parameters [high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), non-high-density lipoprotein cholesterol (Non-HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), remnant cholesterol (RC), and ratios of Non-HDL-C/HDL-C, RC/HDL-C, LDL/HDL-C, TG/HDL-C, TC/HDL-C] in the association of central obesity with diabetes risk. Methods We utilized data from 15,453 participants in the NAGALA longitudinal cohort to assess the association of baseline central obesity indicators [waist-height ratio (WHtR), waist circumference (WC)] and the 11 lipid parameters with diabetes risk. Mediation analysis models were constructed to explore the mediating role of lipid parameters in the association of WC/WHtR with diabetes. Results Confirmatory associative analysis using multivariable Cox regression showed that, except for Non-HDL-C, TC and LD-C, the remaining eight lipid parameters were significantly associated with WC/WHtR and diabetes risk. Mediation analysis indicated that TG, RC, HDL-C, and lipid ratios such as Non-HDL-C/HDL-C ratio, RC/HDL-C ratio, TG/HDL-C ratio, TC/HDL-C ratio and LDL/HDL-C ratio are potential lipids affecting the diabetes risk related to central obesity. Among these, the RC/HDL-C ratio seemed to contribute the most in the WC/WHtR-related diabetes risk association, with a mediation percentage of about 37%. Additionally, lipid ratio parameters appeared to play a more mediating role in the association of central obesity-related diabetes risk than individual lipids. Conclusions In central obesity-related diabetes risk, most lipids, especially lipid ratio parameters, play a significant mediating role. Given these findings, we advocate for increased efforts in multifactorial risk monitoring and joint management of diabetes. The evaluation of lipids, particularly lipid ratio parameters, may be holds substantial value in the prevention and management of diabetes risk under close monitoring of central obesity.https://doi.org/10.1186/s12902-024-01764-5LipidsRC/HDL-C ratioCentral obesityDiabetes |
| spellingShingle | Song Lu Maobin Kuang Jiajun Qiu Wenjuan Li Min Zhang Guotai Sheng Yang Zou Xiaoping Peng Lipids as the link between central obesity and diabetes: perspectives from mediation analysis BMC Endocrine Disorders Lipids RC/HDL-C ratio Central obesity Diabetes |
| title | Lipids as the link between central obesity and diabetes: perspectives from mediation analysis |
| title_full | Lipids as the link between central obesity and diabetes: perspectives from mediation analysis |
| title_fullStr | Lipids as the link between central obesity and diabetes: perspectives from mediation analysis |
| title_full_unstemmed | Lipids as the link between central obesity and diabetes: perspectives from mediation analysis |
| title_short | Lipids as the link between central obesity and diabetes: perspectives from mediation analysis |
| title_sort | lipids as the link between central obesity and diabetes perspectives from mediation analysis |
| topic | Lipids RC/HDL-C ratio Central obesity Diabetes |
| url | https://doi.org/10.1186/s12902-024-01764-5 |
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