Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma

Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma

Abstract Sensitive diagnostics are needed to improve management and surveillance of opisthorchiasis and opisthorchiasis-associated cholangiocarcinoma (CCA) throughout East Asia. Herein we generate and screen an Opisthorchis viverrini recombinant secreted proteome to identity antibody biomarkers of l...

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Main Authors: Lakkhana Sadaow, Rutchanee Rodpai, Michael J. Smout, Rie Nakajima, Patcharaporn Boonroumkaew, Javier Sotillo, Bemnet A. Tedla, Vor Luvira, Amnat Kitkhuandee, Krisada Paonariang, Wattana Sukeepaisarnjaroen, Hiroshi Yamasaki, Sutas Suttiprapa, Thewarach Laha, Banchob Sripa, Rafael de Assis, Aarti Jain, Wannaporn Ittiprasert, Victoria H. Mann, Yide Wong, Philip L. Felgner, Wanchai Maleewong, Paul J. Brindley, Alex Loukas, Pewpan M. Intapan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61043-2
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https://doi.org/10.1038/s41467-025-61043-2

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