Synthesis and in vitro evaluation of novel pH-triggered biocompatible folate-chondroitin sulfate-dexamethasone copolymers for delivery of tofacitinib in rheumatoid arthritis

Synthesis and in vitro evaluation of novel pH-triggered biocompatible folate-chondroitin sulfate-dexamethasone copolymers for delivery of tofacitinib in rheumatoid arthritis

Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with systemic complications and progressive disability. Systemic side effects and poor drug delivery to joints limit current treatments. This study aimed to enhance the efficacy of tofacitinib (Tofa) by sy...

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Bibliographic Details
Main Authors:	Zahra Ansarypour, Jaber Emami, Farshid Hassanzadeh, Mahmoud Aghaei, Mohsen Minaiyan, Neal M. Davies, Mahboubeh Rezazadeh
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-05-01
Series:	Research in Pharmaceutical Sciences
Subjects:	chondroitin sulfate dexamethasone folic acid tofacitinib ph-sensitive copolymers rheumatoid arthritis
Online Access:	https://journals.lww.com/10.4103/RPS.RPS_40_25
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