Case Report: When dual immune checkpoint blockade strikes back: cadonilimab-induced hypersensitivity in solid tumors — a case series and review

Case Report: When dual immune checkpoint blockade strikes back: cadonilimab-induced hypersensitivity in solid tumors — a case series and review

BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but immune-related hypersensitivity reactions remain a clinical concern. Cadonilimab, a novel PD-1/CTLA-4 bispecific antibody, has demonstrated encouraging antitumor efficacy across various solid tumors; however, hyper...

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Bibliographic Details
Main Authors: Ping Song, Yuqi Jin, Linglin Fu, Fengming Yang, Yinuo Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
cadonilimab
hypersensitivity reaction
infusion-related reaction
immune checkpoint inhibitor
case report
literature review
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1643279/full
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