Advanced preclinical functional magnetic resonance imaging of the brain
Abstract Functional magnetic resonance imaging (fMRI), exploiting the blood oxygen level-dependent (BOLD) contrast, is the most widely used technique to study brain function. Combined with tools from biotechnology, molecular biology, and genetics, preclinical fMRI offers unparalleled opportunities t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Imaging |
| Online Access: | https://doi.org/10.1038/s44303-025-00085-z |
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| _version_ | 1849685946122895360 |
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| author | Jan Klohs Way Cherng Chen Rikita Araki |
| author_facet | Jan Klohs Way Cherng Chen Rikita Araki |
| author_sort | Jan Klohs |
| collection | DOAJ |
| description | Abstract Functional magnetic resonance imaging (fMRI), exploiting the blood oxygen level-dependent (BOLD) contrast, is the most widely used technique to study brain function. Combined with tools from biotechnology, molecular biology, and genetics, preclinical fMRI offers unparalleled opportunities to experimentally test causal hypotheses that are beyond the reach of human research. Here, we review recent progress in MRI hardware development, provide recommendations for BOLD fMRI protocol optimization, and discuss recent applications. |
| format | Article |
| id | doaj-art-39d3c49bbed74d6a91eceb1c19c589aa |
| institution | DOAJ |
| issn | 2948-197X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Imaging |
| spelling | doaj-art-39d3c49bbed74d6a91eceb1c19c589aa2025-08-20T03:22:54ZengNature Portfolionpj Imaging2948-197X2025-06-013111210.1038/s44303-025-00085-zAdvanced preclinical functional magnetic resonance imaging of the brainJan Klohs0Way Cherng Chen1Rikita Araki2Bruker BioSpin GmbH & Co. KGBruker Singapore Pte. LtdBruker Japan K.KAbstract Functional magnetic resonance imaging (fMRI), exploiting the blood oxygen level-dependent (BOLD) contrast, is the most widely used technique to study brain function. Combined with tools from biotechnology, molecular biology, and genetics, preclinical fMRI offers unparalleled opportunities to experimentally test causal hypotheses that are beyond the reach of human research. Here, we review recent progress in MRI hardware development, provide recommendations for BOLD fMRI protocol optimization, and discuss recent applications.https://doi.org/10.1038/s44303-025-00085-z |
| spellingShingle | Jan Klohs Way Cherng Chen Rikita Araki Advanced preclinical functional magnetic resonance imaging of the brain npj Imaging |
| title | Advanced preclinical functional magnetic resonance imaging of the brain |
| title_full | Advanced preclinical functional magnetic resonance imaging of the brain |
| title_fullStr | Advanced preclinical functional magnetic resonance imaging of the brain |
| title_full_unstemmed | Advanced preclinical functional magnetic resonance imaging of the brain |
| title_short | Advanced preclinical functional magnetic resonance imaging of the brain |
| title_sort | advanced preclinical functional magnetic resonance imaging of the brain |
| url | https://doi.org/10.1038/s44303-025-00085-z |
| work_keys_str_mv | AT janklohs advancedpreclinicalfunctionalmagneticresonanceimagingofthebrain AT waycherngchen advancedpreclinicalfunctionalmagneticresonanceimagingofthebrain AT rikitaaraki advancedpreclinicalfunctionalmagneticresonanceimagingofthebrain |