Co-expression of IL-15/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK/STAT5 signaling pathway

Co-expression of IL-15/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK/STAT5 signaling pathway

The application of CAR T therapy has significantly improved the efficacy of hematological tumors. However, there are still some challenges in the treatment of solid tumors, mainly because the complex immune microenvironment affects the proliferation of T cells, making T cells unable to function well...

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Bibliographic Details
Main Authors: Yiran Chen, Chenxu Jin, Dandan Guo, Xinhui Hui, Yuzhou Ji, Yunhe Huang, Min Xue, Yaoxin Gao, Yaojun Ren, Haizhen Lin, Ying Zhou, Wenzheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
NKG2D
CAR T
IL-15
pancreatic carcinoma
JAK/STAT5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1498706/full
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