Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination

Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination

Abstract Background Epigenetic reprogramming shapes immune memory in both innate (trained immunity) and adaptive immune cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the role of dynamic DNA methylation changes in post-vaccination immune responses remains unclear. Results We es...

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Main Authors: Cancan Qi, Zhaoli Liu, Gizem Kilic, Andrei S. Sarlea, Priya A. Debisarun, Xuan Liu, Yonatan Ayalew Mekonnen, Wenchao Li, Martin Grasshoff, Ahmed Alaswad, Apostolos Petkoglou, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
BCG vaccination
Cytokines response
Trained immunity
DNA methylation
Systems biology
Online Access:https://doi.org/10.1186/s13059-025-03611-9
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https://doi.org/10.1186/s13059-025-03611-9

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