Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths

Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths

Abstract Telomeres are terminal protective chromosome structures. Genetic variants in genes coding for proteins required for telomere maintenance cause rare, life-threatening Telomere Biology Disorders (TBDs) such as dyskeratosis congenita, aplastic anemia or pulmonary fibrosis. The more frequently...

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Main Authors: Rosa Guerrero-López, Cristina Manguán-García, Carlos Carrascoso-Rubio, M. Luz Lozano, Marta Toldos-Torres, Laura García-Castro, Rebeca Sánchez-Dominguez, Omaira Alberquilla, Isabel Sánchez-Pérez, Maria Molina-Molina, Juan A. Bueren, Guillermo Guenechea, Rosario Perona, Leandro Sastre
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Terc
Telomere biology disorders
Telomeres
Pulmonary fibrosis
Aplastic anemia
CAST/EiJ
Online Access:https://doi.org/10.1038/s41598-025-90246-2
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https://doi.org/10.1038/s41598-025-90246-2

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