Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling

Preadipocyte-induced upregulation of IGFBP5 enhances ovarian cancer tumorigenesis via CREB signaling

Summary: Dissemination of ovarian cancer cells during metastasis is heavily influenced by omental cells from the adipose tumor microenvironment. We previously found that omental adipocyte precursors, or preadipocytes, promote stress tolerance and tumorigenesis of ovarian cancer cells and this was co...

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Bibliographic Details
Main Authors: Jennifer A. Waters, Cassidy Lucht, Sofia Howe, Gregory J. Jordan, Ixchel Urbano, Samuel F. Gilbert, Richard M. Cripps, Mikella Robinson, Carrie D. House
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Cancer
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012957
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