Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients
Background: We conducted this study to investigate and evaluate the correlation between the serum parathyroid hormone (PTH) concentrations and 24-hour ABPM parameters in hypertensive patients Methods and Results: A cross-sectional descriptive study was conducted in the Cardiology Department of Hue...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2024-12-01
|
| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i56/ijbm_14(4)_oa1.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846138739082919936 |
|---|---|
| author | Chi Thang Doan Van Minh Huynh Cong Huy Nguyen |
| author_facet | Chi Thang Doan Van Minh Huynh Cong Huy Nguyen |
| author_sort | Chi Thang Doan |
| collection | DOAJ |
| description | Background: We conducted this study to investigate and evaluate the correlation between the serum parathyroid hormone (PTH) concentrations and 24-hour ABPM parameters in hypertensive patients
Methods and Results: A cross-sectional descriptive study was conducted in the Cardiology Department of Hue Central Hospital on 74 hypertensive patients. All patients underwent 24-hour ABPM. Serum PTH was measured using a sandwich electrochemiluminescence immunoassay on a Cobas 8000. The mean values of daytime systolic blood pressure (SBP), daytime diastolic blood pressure (DBP), nighttime SBP, and nighttime DBP were 127.74±14.44 mmHg, 77.24±9.01 mmHgm, 122.86±16.57 mmHg, and 76.92±11.69 mmHg, respectively. The median value of serum PTH concentration was 68.6 pg/mL (39.83 pg/mL - 87.46 pg/mL).
All patients were divided into two groups. Group 1 included 40 AH patients with serum PTH >65 pg/mL, and Group 2 included 34 AH patients with serum PTH≤65 pg/mL. The mean values of 24-hour SBP, nighttime SBP, nighttime DBP, and nighttime mean blood pressure (MBP) in Group 1 were significantly higher than in Group 2 (P<0.05). Meanwhile, the patients of Group 1 had a statistically significantly higher rate of nocturnal blood pressure dipping and early morning blood pressure surge than the patients of Group 2 (P<0.01). We found a moderate positive correlation between serum PTH concentration and nighttime SBP (r=0.595; P<0.001), nighttime DBP (r=0.666; P<0.001), and nighttime MBP (r=0.560; P<0.001). In multivariate regression analysis, only nighttime SBP and nighttime DBP were two independent factors that significantly predicted the PTH index.
Conclusion: The serum PTH concentration shows a moderate positive correlation with nocturnal DBP, nocturnal SBP, and nocturnal MBP. Only nocturnal DBP and nocturnal SBP are independent factors significantly predicting PTH levels. |
| format | Article |
| id | doaj-art-2b07c401ed614d969ac15f65389a8ba9 |
| institution | Kabale University |
| issn | 2158-0510 2158-0529 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj-art-2b07c401ed614d969ac15f65389a8ba92024-12-07T00:35:43ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292024-12-0114454555010.21103/Article14(4)_OA1Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive PatientsChi Thang Doan0Van Minh Huynh1Cong Huy Nguyen2Department of Cardiology, Hue Central Hospital, Hue city, Vietnam Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue University, Hue city, VietnamDepartment of Internal Medicine, Phuc Hung Private General Hospital, Quang Ngai, VietnamBackground: We conducted this study to investigate and evaluate the correlation between the serum parathyroid hormone (PTH) concentrations and 24-hour ABPM parameters in hypertensive patients Methods and Results: A cross-sectional descriptive study was conducted in the Cardiology Department of Hue Central Hospital on 74 hypertensive patients. All patients underwent 24-hour ABPM. Serum PTH was measured using a sandwich electrochemiluminescence immunoassay on a Cobas 8000. The mean values of daytime systolic blood pressure (SBP), daytime diastolic blood pressure (DBP), nighttime SBP, and nighttime DBP were 127.74±14.44 mmHg, 77.24±9.01 mmHgm, 122.86±16.57 mmHg, and 76.92±11.69 mmHg, respectively. The median value of serum PTH concentration was 68.6 pg/mL (39.83 pg/mL - 87.46 pg/mL). All patients were divided into two groups. Group 1 included 40 AH patients with serum PTH >65 pg/mL, and Group 2 included 34 AH patients with serum PTH≤65 pg/mL. The mean values of 24-hour SBP, nighttime SBP, nighttime DBP, and nighttime mean blood pressure (MBP) in Group 1 were significantly higher than in Group 2 (P<0.05). Meanwhile, the patients of Group 1 had a statistically significantly higher rate of nocturnal blood pressure dipping and early morning blood pressure surge than the patients of Group 2 (P<0.01). We found a moderate positive correlation between serum PTH concentration and nighttime SBP (r=0.595; P<0.001), nighttime DBP (r=0.666; P<0.001), and nighttime MBP (r=0.560; P<0.001). In multivariate regression analysis, only nighttime SBP and nighttime DBP were two independent factors that significantly predicted the PTH index. Conclusion: The serum PTH concentration shows a moderate positive correlation with nocturnal DBP, nocturnal SBP, and nocturnal MBP. Only nocturnal DBP and nocturnal SBP are independent factors significantly predicting PTH levels.http://www.ijbm.org/articles/i56/ijbm_14(4)_oa1.pdfarterial hypertensionparathyroid hormoneambulatory blood pressure monitoring |
| spellingShingle | Chi Thang Doan Van Minh Huynh Cong Huy Nguyen Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients International Journal of Biomedicine arterial hypertension parathyroid hormone ambulatory blood pressure monitoring |
| title | Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients |
| title_full | Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients |
| title_fullStr | Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients |
| title_full_unstemmed | Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients |
| title_short | Relationship between Serum Parathyroid Hormone Levels and 24-Hour Ambulatory Blood Pressure Monitoring Parameters in Hypertensive Patients |
| title_sort | relationship between serum parathyroid hormone levels and 24 hour ambulatory blood pressure monitoring parameters in hypertensive patients |
| topic | arterial hypertension parathyroid hormone ambulatory blood pressure monitoring |
| url | http://www.ijbm.org/articles/i56/ijbm_14(4)_oa1.pdf |
| work_keys_str_mv | AT chithangdoan relationshipbetweenserumparathyroidhormonelevelsand24hourambulatorybloodpressuremonitoringparametersinhypertensivepatients AT vanminhhuynh relationshipbetweenserumparathyroidhormonelevelsand24hourambulatorybloodpressuremonitoringparametersinhypertensivepatients AT conghuynguyen relationshipbetweenserumparathyroidhormonelevelsand24hourambulatorybloodpressuremonitoringparametersinhypertensivepatients |