Biomarkers of GH deficiency identified in untreated and GH-treated Pit-1 mutant mice

BackgroundGrowth Hormone Deficiency (GHD) is marked by insufficient growth hormone (GH) production, leading to disruptions in growth and metabolism. Its diagnosis is challenging due to the lack of sensitive, specific tests. To address this, we used a novel mouse model with a POU1F1 (Pit-1) gene muta...

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Main Authors: Sarmed Al-Samerria, Huiting Xu, M. Elena Diaz-Rubio, Joseph Phelan, Chi Su, Keer Ma, Anna Newen, Kiana Li, Sayaka Yamada, Ariel L. Negron, Fredric Wondisford, Sally Radovick
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Endocrinology
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Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1539797/full
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