PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma
Abstract Background Preferentially expressed antigen in melanoma (PRAME) is a promising immunohistochemical marker for distinguishing benign from malignant melanocytic lesions in lymph node deposits. Objective To evaluate PRAME expression in metastatic melanomas and nevi found in the sentinel lymph...
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BMC
2024-12-01
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| Series: | Surgical and Experimental Pathology |
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| Online Access: | https://doi.org/10.1186/s42047-024-00171-3 |
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| author | Hortência Gomes da Silveira Hercilio Fronza Junior Larissa D’Espirro de Souza Campos Jaqueline Stall Rodrigo Blasius Camila Kricheski Bruna Louise Silva Paulo Henrique Condeixa de França Karina Munhoz de Paula Alves Coelho |
| author_facet | Hortência Gomes da Silveira Hercilio Fronza Junior Larissa D’Espirro de Souza Campos Jaqueline Stall Rodrigo Blasius Camila Kricheski Bruna Louise Silva Paulo Henrique Condeixa de França Karina Munhoz de Paula Alves Coelho |
| author_sort | Hortência Gomes da Silveira |
| collection | DOAJ |
| description | Abstract Background Preferentially expressed antigen in melanoma (PRAME) is a promising immunohistochemical marker for distinguishing benign from malignant melanocytic lesions in lymph node deposits. Objective To evaluate PRAME expression in metastatic melanomas and nevi found in the sentinel lymph nodes of patients with primary melanoma. Methods Thirty patients, comprising 15 nodal nevi and 15 metastatic melanomas, were immunohistochemically analyzed for PRAME expression. Nuclear expression was scored as 0–25%, > 25–50%, > 50–75% or > 75% in tumor cells. The sensitivity, specificity, and positive and negative predictive values were calculated considering nuclear expression of PRAME > 75% as positive cases. Results Cases previously diagnosed as nodal nevi were uniformly negative for PRAME. Conversely, all cases diagnosed as melanoma showed PRAME expression in more than 50% of the cells. Twelve cases showed expression above 75% of cells and were considered positive for calculations, resulting in sensitivity and specificity rates of 80% and 100%, respectively, with corresponding positive and negative predictive values of 100% and 83%. Conclusions A high level of PRAME immunoreactivity was identified in metastatic melanoma, suggesting that PRAME is a useful analytical tool for confirming the diagnosis of melanoma in a melanocytic nodal deposit. |
| format | Article |
| id | doaj-art-1f6e794b392a4eddb044d37a7894269e |
| institution | Kabale University |
| issn | 2520-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Surgical and Experimental Pathology |
| spelling | doaj-art-1f6e794b392a4eddb044d37a7894269e2024-12-22T12:24:39ZengBMCSurgical and Experimental Pathology2520-84542024-12-01711710.1186/s42047-024-00171-3PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanomaHortência Gomes da Silveira0Hercilio Fronza Junior1Larissa D’Espirro de Souza Campos2Jaqueline Stall3Rodrigo Blasius4Camila Kricheski5Bruna Louise Silva6Paulo Henrique Condeixa de França7Karina Munhoz de Paula Alves Coelho8Universidade da Região de Joinville - UNIVILLECentro de Diagnósticos Anátomo-Patológicos - CEDAPCentro de Diagnósticos Anátomo-Patológicos - CEDAPUniversidade da Região de Joinville - UNIVILLECentro de Diagnósticos Anátomo-Patológicos - CEDAPCentro de Diagnósticos Anátomo-Patológicos - CEDAPUniversidade da Região de Joinville - UNIVILLEUniversidade da Região de Joinville - UNIVILLEUniversidade da Região de Joinville - UNIVILLEAbstract Background Preferentially expressed antigen in melanoma (PRAME) is a promising immunohistochemical marker for distinguishing benign from malignant melanocytic lesions in lymph node deposits. Objective To evaluate PRAME expression in metastatic melanomas and nevi found in the sentinel lymph nodes of patients with primary melanoma. Methods Thirty patients, comprising 15 nodal nevi and 15 metastatic melanomas, were immunohistochemically analyzed for PRAME expression. Nuclear expression was scored as 0–25%, > 25–50%, > 50–75% or > 75% in tumor cells. The sensitivity, specificity, and positive and negative predictive values were calculated considering nuclear expression of PRAME > 75% as positive cases. Results Cases previously diagnosed as nodal nevi were uniformly negative for PRAME. Conversely, all cases diagnosed as melanoma showed PRAME expression in more than 50% of the cells. Twelve cases showed expression above 75% of cells and were considered positive for calculations, resulting in sensitivity and specificity rates of 80% and 100%, respectively, with corresponding positive and negative predictive values of 100% and 83%. Conclusions A high level of PRAME immunoreactivity was identified in metastatic melanoma, suggesting that PRAME is a useful analytical tool for confirming the diagnosis of melanoma in a melanocytic nodal deposit.https://doi.org/10.1186/s42047-024-00171-3PRAMEImmunohistochemistryMetastatic melanomaMelanocytic neviSentinel lymph nodes |
| spellingShingle | Hortência Gomes da Silveira Hercilio Fronza Junior Larissa D’Espirro de Souza Campos Jaqueline Stall Rodrigo Blasius Camila Kricheski Bruna Louise Silva Paulo Henrique Condeixa de França Karina Munhoz de Paula Alves Coelho PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma Surgical and Experimental Pathology PRAME Immunohistochemistry Metastatic melanoma Melanocytic nevi Sentinel lymph nodes |
| title | PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| title_full | PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| title_fullStr | PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| title_full_unstemmed | PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| title_short | PRAME immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| title_sort | prame immunohistochemistry distinguishes nodal nevi from metastatic melanoma |
| topic | PRAME Immunohistochemistry Metastatic melanoma Melanocytic nevi Sentinel lymph nodes |
| url | https://doi.org/10.1186/s42047-024-00171-3 |
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