Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds

Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds

Abstract In this study, a highly feasible fabrication approach is explored to make flexible elastomer molds for producing transdermal patches comprising an array of millimeter‐long dissolvable polymer needles. The millineedles (MilN), produced in both polyvinylpyrrolidone and carboxymethyl cellulose...

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Bibliographic Details
Main Authors: Matteo Tollemeto, Lasse Højlund Eklund Thamdrup, Veni Mahalingam, Gavrielle R. Untracht, Tania Patiño Padial, Peter Eskil Andersen, Jan van Hest, Anja Boisen
Format: Article
Language:English
Published: Wiley-VCH 2025-05-01
Series:Advanced Materials Interfaces
Subjects:
mesoporous silica nanoparticles
millineedles
OCT
transdermal delivery
Online Access:https://doi.org/10.1002/admi.202400858
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Summary:Abstract In this study, a highly feasible fabrication approach is explored to make flexible elastomer molds for producing transdermal patches comprising an array of millimeter‐long dissolvable polymer needles. The millineedles (MilN), produced in both polyvinylpyrrolidone and carboxymethyl cellulose, are targeting efficient transdermal drug delivery. Employing a fast, inexpensive, and reproducible CO2 laser ablation process, polydimethylsiloxane molds are successfully created measuring 10 × 10 mm2, with arrays of conical cavities reaching depths of 1288.17 ± 128.93 µm. While this versatile fabrication technique is previously demonstrated for microneedles, it lacked a comprehensive performance evaluation of the produced needles. The study fills this gap by providing significant experimental data on the in vitro and ex vivo performance of the MilN patches. The applicability of the method is demonstrated by systematically casting and testing patches comprising various hydrophilic polymers and compounds. Mechanical testing underscored the resilience of MilN arrays, enduring compression forces up to 36 N for 30 s. Skin penetration efficiency, assessed in Parafilm M and porcine skin, revealed an insertion depth of ≈560 µm for polyvinylpyrrolidone MilN.
ISSN:2196-7350

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