The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Abstract Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin spreading and maintenance network,...

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Main Authors: Nitika Gaurav, Ryan O’Hara, Usman Hyder, Weihua Qin, Cheenou Her, Hector Romero, Amarjeet Kumar, Maria J. Marcaida, Rohit K. Singh, Ruud Hovius, Karthik Selvam, Jiuyang Liu, Sara Martire, Yuhang Yao, Ashwini Challa, Matteo Dal Peraro, Beat Fierz, Hidetoshi Kono, M. Cristina Cardoso, Galia T. Debelouchina, Heinrich Leonhardt, Iván D’Orso, Laura A. Banaszynski, Tatiana G. Kutateladze
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60279-2
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https://doi.org/10.1038/s41467-025-60279-2

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