Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats

Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats

Spinal cord injury (SCI) triggers an inflammatory response that is partially mediated by the inflammasome and the production of pro-inflammatory cytokines. We have previously shown that pannexin-1 is involved in the activation of the inflammasome, and that probenecid inhibits this caspase-1-mediated...

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Bibliographic Details
Main Authors: Toru Asari, Sunao Tanaka, Damien D. Pearse, Juan Pablo de Rivero Vaccari, Toshitada Sawada, Yasuyuki Ishibashi, Robert W. Keane, W. Dalton Dietrich
Format: Article
Language:English
Published: Mary Ann Liebert 2025-01-01
Series:Neurotrauma Reports
Subjects:
inflammasome
probenecid
Pannexin-1
spinal cord injury
Online Access:https://www.liebertpub.com/doi/10.1089/neur.2025.0044
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