Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients

Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients

Jose Miguel Escamilla-Gil,1– 3 Carlos A Torres-Duque,2,3 Kevin Llinás-Caballero,1 Nadia Juliana Proaños-Jurado,2,3 María M De Vivero,1 Jonathan Camilo Ramirez,1 Ronald Regino,1 Lucila Teresa Florez de Arco,4 Rodolfo Dennis,5,6 Mauricio González-García,2,3 Luis Caraballo,1 Nathalie Acevedo1 1Institut...

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Main Authors: Escamilla-Gil JM, Torres-Duque CA, Llinás-Caballero K, Proaños-Jurado NJ, De Vivero MM, Ramirez JC, Regino R, Florez de Arco LT, Dennis R, González-García M, Caraballo L, Acevedo N
Format: Article
Language:English
Published: Dove Medical Press 2025-04-01
Series:International Journal of COPD
Subjects:
biomarkers
proximity extension assay
chronic obstructive pulmonary disease
circulating inflammatory mediators
cxcl9
mcp-3
Online Access:https://www.dovepress.com/plasma-levels-of-cxcl9-and-mcp-3-are-increased-in-asthma-copd-overlap--peer-reviewed-fulltext-article-COPD
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Summary:Jose Miguel Escamilla-Gil,1– 3 Carlos A Torres-Duque,2,3 Kevin Llinás-Caballero,1 Nadia Juliana Proaños-Jurado,2,3 María M De Vivero,1 Jonathan Camilo Ramirez,1 Ronald Regino,1 Lucila Teresa Florez de Arco,4 Rodolfo Dennis,5,6 Mauricio González-García,2,3 Luis Caraballo,1 Nathalie Acevedo1 1Institute for Immunological Research, University of Cartagena, Cartagena, Colombia; 2CINEUMO, Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; 3La Sabana University, School of Medicine, Bogotá, Colombia; 4Respiratory and Allergy Clinic, Cartagena, Colombia; 5Cardioinfantil Foundation, Bogotá, Colombia; 6Universidad del Rosario, Bogotá, ColombiaCorrespondence: Nathalie Acevedo, Institute for Immunological Research. University of Cartagena. Health Sciences Campus Zaragocilla. Ed. Biblioteca Piso 1, Cartagena, 1300014, Colombia, Email nacevedoc@unicartagena.edu.coPurpose: Asthma and chronic obstructive pulmonary disease overlap patients (ACO) have more exacerbations and a worse prognosis than pure asthma or COPD, and it is of great interest to identify differential biomarkers of ACO. We compared blood eosinophil counts, plasma IgE and protein levels among patients with asthma, ACO, COPD, and healthy subjects to identify those associated with ACO.Patients and Methods: 397 adults (age 40– 90 years) were recruited from two Colombian cities: asthma (n=123), COPD (n=100), ACO (n=74) and healthy control (HC, n=100). Plasma protein levels were measured using the Proximity Extension Assay (Olink Proteomics).Results: There were no differences in blood eosinophil counts between the patient groups. Total and specified IgE levels were higher in patients with ACO than in those with COPD. Ten plasma proteins showed significant differences between the patients with ACO and HC. In patients above 60 years old, CXCL9 discriminates ACO from asthma patients with AUC 0.73 (0.63– 0.82, DeLong test p=0.007), and in patients below 60 years old, MCP-3 discriminates ACO from COPD patients with AUC 0.84 (0.62– 1.0, DeLong test p=0.006). CUB domain-containing protein 1 (CDCP1) levels (OR, 0.47; p=0.008) and age > 60 years (OR, 0.25; p=0.001) were negatively associated with ACO.Conclusion: CXCL9 levels could be used to discriminate ACO from asthma patients and MCP-3 to discriminate ACO from COPD. Protein inflammatory signatures in plasma of ACO patients were similar to the COPD group. This study revealed novel biomarkers that may help characterize patients with ACO.Keywords: biomarkers, proximity extension assay, PEA, chronic obstructive pulmonary disease, COPD, circulating inflammatory mediators, CXCL9, MCP-3
ISSN:1178-2005

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