Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions

Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions

G-quadruplexes (G4s) are distinctive four-stranded nucleic acid structures formed by guanine-rich sequences, making them attractive targets for drug repurposing efforts. Modulating their stability and function holds promise for treating diseases like cancer. To identify potential drug candidates cap...

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Bibliographic Details
Main Authors: Gianmarco Gualtieri, Emanuele Liborio Citriniti, Roberta Rocca, Valentina Arciuolo, Jussara Amato, Antonio Randazzo, Stefano Alcaro
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
G-quadruplex
kanamycin
drug repurposing
docking
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/29/24/5932
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