Pin1/YAP pathway mediates matrix stiffness‐induced epithelial–mesenchymal transition driving cervical cancer metastasis via a non‐Hippo mechanism

Pin1/YAP pathway mediates matrix stiffness‐induced epithelial–mesenchymal transition driving cervical cancer metastasis via a non‐Hippo mechanism

Abstract Cervical cancer metastasis is an important cause of death in cervical cancer. Previous studies have shown that epithelial–mesenchymal transition (EMT) of tumors promotes its invasive and metastatic capacity. Alterations in the extracellular matrix (ECM) and mechanical signaling are closely...

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Main Authors: Long Yang, Jingwen Li, Guangchao Zang, Sijie Song, Zhengwen Sun, Xinyue Li, Yuanzhu Li, Zhenhong Xie, Guangyuan Zhang, Ni Gui, Shu Zhu, Tingting Chen, Yikui Cai, Yinping Zhao
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Bioengineering & Translational Medicine
Subjects:
epithelial–mesenchymal transition
extracellular matrix stiffness
PPIase non‐mitotic a‐interaction 1
yes‐associated protein
Online Access:https://doi.org/10.1002/btm2.10375
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https://doi.org/10.1002/btm2.10375

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