Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions
Abstract Breast cancer resistance protein (BCRP), a member of the ATP-binding cassette transporter family, plays a key role in the efflux of various drugs and is linked to multidrug resistance in cancer therapy. Flavonoids, particularly those with a flavonol backbone, have shown promise as inhibitor...
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| Main Authors: | Kyeong-Ryoon Lee, Min-Ji Kang, Min Ju Kim, Yiseul Im, Hyeon-Cheol Jeong, Yoon-Jee Chae |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-13908-1 |
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