White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI

White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI

Abstract Thalassemia is a hereditary hemoglobinopathy characterized by severe anemia and iron overload, which may affect brain microstructure. This study aims to investigate changes in the white matter (WM) microstructure of patients with β-thalassemia using diffusion tensor imaging (DTI) and tract-...

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Bibliographic Details
Main Authors: Mingrui Yang, Guowei Chen, Chaotian Luo, Cheng Tang, Fei Peng, Rong Kong, Peng Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Thalassemia
White matter
Diffusion tensor imaging
Tract-based spatial statistics
Microstructural abnormalities
Iron overload
Online Access:https://doi.org/10.1038/s41598-025-99505-8
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