A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching

A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching

ABSTRACT Solid organ transplant recipients (SOTRs) suffer more frequent and more severe infections due to their compromised immune responses resulting from immunosuppressive treatments designed to prevent organ rejection. Pharmacological immunosuppression can adversely affect immune responses to vac...

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Main Authors: Jenny M. Lee, Jaiprasath Sachithanandham, John S. Lee, Janna R. Shapiro, Maggie Li, Ioannis Sitaris, Stephanie R. Peralta, Camille Wouters, Andrea L. Cox, Dorry L. Segev, Christine M. Durand, Mark Robien, Aaron A. R. Tobian, Andrew H. Karaba, Joel N. Blankson, William A. Werbel, Andrew Pekosz, Sabra L. Klein
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
COVID-19
immunocompromised hosts
SARS-CoV-2
IgG isotype
vaccines
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02190-24
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https://journals.asm.org/doi/10.1128/spectrum.02190-24

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