Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate Ca<sup>2+</sup> Cycling, Voltage Dependence, and Spark Characteristics

Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate Ca<sup>2+</sup> Cycling, Voltage Dependence, and Spark Characteristics

Previous studies have observed alterations in excitation–contraction (EC) coupling during end-stage heart failure that include action potential and calcium (Ca<sup>2+</sup>) transient prolongation and a reduction of the Ca<sup>2+</sup> transient amplitude. Underlying these ph...

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Bibliographic Details
Main Authors: Jerome Anthony E. Alvarez, Mohsin Saleet Jafri, Aman Ullah
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomolecules
Subjects:
calcium
heart failure
calcium sparks
ventricular myocyte
cardiac cell
ionic currents
Online Access:https://www.mdpi.com/2218-273X/14/11/1371
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