Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study
Introduction Pre-eclampsia is a pregnancy-related complication estimated to affect up to 8% of pregnancies worldwide. It is associated with an increased risk of postpartum sustained hypertension, coronary artery disease, cerebrovascular disease, peripheral arterial disease and cardiovascular-related...
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/12/e091882.full |
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| author | Albertino Damasceno Amabelia Rodrigues Nuno Lunet Ruben Turé Eunice Barai Almame Cissé Gabriel Sanca Tida Iafa Waldir Jalo Bubacar Embalo Marcos Dju Vasco Iala |
| author_facet | Albertino Damasceno Amabelia Rodrigues Nuno Lunet Ruben Turé Eunice Barai Almame Cissé Gabriel Sanca Tida Iafa Waldir Jalo Bubacar Embalo Marcos Dju Vasco Iala |
| author_sort | Albertino Damasceno |
| collection | DOAJ |
| description | Introduction Pre-eclampsia is a pregnancy-related complication estimated to affect up to 8% of pregnancies worldwide. It is associated with an increased risk of postpartum sustained hypertension, coronary artery disease, cerebrovascular disease, peripheral arterial disease and cardiovascular-related mortality. Nevertheless, these associations have seldom been addressed in younger women from sub-Saharan Africa (SSA). Hence, this study aims to assess the association between pre-eclampsia and cardiovascular impairment within the first year after delivery, among younger women in SSA.Methods and analysis This is a prospective cohort study conducted at Hospital Nacional Simão Mendes in Bissau, Guinea-Bissau. A total of 230 pregnant women aged below 25 years (115 diagnosed with pre-eclampsia and 115 normotensive age-matched pregnancies), will be enrolled after their 20th gestational week. Exclusion criteria include diabetes, hypertension or other serious maternal diseases present before pregnancy. Participants will be assessed at baseline (pre-labour period), 4 and 12 months after delivery; evaluations started in March 2023 and are expected to end in December 2026. At each follow-up assessment, the women will have their blood pressure measured with a digital sphygmomanometer and a 24-hour ambulatory blood pressure monitor. Cardiac and renal function will be assessed using echocardiography and laboratory testing, respectively. Primary outcomes include the mean differences in cardiovascular and renal parameters between women who had pre-eclampsia and those who had normotensive pregnancies. Age, parity, age at first pregnancy, family history of cardiovascular diseases, smoking habits, gestational diabetes diagnosed before pre-eclampsia, body mass index and labour complications will be considered a priori as potential confounders of the association between pre-eclampsia and postpartum cardiovascular impairment.Ethics and dissemination This study was approved by the Comité Nacional de Ética em Pesquisa na Saúde, Guinea-Bissau (008/CNES/INASA/2023), and participants provide written informed consent. Results will be disseminated among the scientific community and the public. |
| format | Article |
| id | doaj-art-0469224cae5845fcae588c3456f2b834 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0469224cae5845fcae588c3456f2b8342025-01-14T15:25:15ZengBMJ Publishing GroupBMJ Open2044-60552024-12-01141210.1136/bmjopen-2024-091882Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort studyAlbertino Damasceno0Amabelia Rodrigues1Nuno Lunet2Ruben Turé3Eunice Barai4Almame Cissé5Gabriel Sanca6Tida Iafa7Waldir Jalo8Bubacar Embalo9Marcos Dju10Vasco Iala113 University of Eduardo Mondlane Faculty of Medicine, Maputo, Mozambique4 Bandim Health Project, Bissau, Guinea-Bissau1 EPIunit and Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto Instituto de Saude Publica, Porto, Portugal2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau6 Cooperativa Médico Sanitária Madrugada de Bissau, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau2 Hospital Nacional Simão Mendes, Bissau, Guinea-Bissau7 Hospital Militar, Bissau, Guinea-BissauIntroduction Pre-eclampsia is a pregnancy-related complication estimated to affect up to 8% of pregnancies worldwide. It is associated with an increased risk of postpartum sustained hypertension, coronary artery disease, cerebrovascular disease, peripheral arterial disease and cardiovascular-related mortality. Nevertheless, these associations have seldom been addressed in younger women from sub-Saharan Africa (SSA). Hence, this study aims to assess the association between pre-eclampsia and cardiovascular impairment within the first year after delivery, among younger women in SSA.Methods and analysis This is a prospective cohort study conducted at Hospital Nacional Simão Mendes in Bissau, Guinea-Bissau. A total of 230 pregnant women aged below 25 years (115 diagnosed with pre-eclampsia and 115 normotensive age-matched pregnancies), will be enrolled after their 20th gestational week. Exclusion criteria include diabetes, hypertension or other serious maternal diseases present before pregnancy. Participants will be assessed at baseline (pre-labour period), 4 and 12 months after delivery; evaluations started in March 2023 and are expected to end in December 2026. At each follow-up assessment, the women will have their blood pressure measured with a digital sphygmomanometer and a 24-hour ambulatory blood pressure monitor. Cardiac and renal function will be assessed using echocardiography and laboratory testing, respectively. Primary outcomes include the mean differences in cardiovascular and renal parameters between women who had pre-eclampsia and those who had normotensive pregnancies. Age, parity, age at first pregnancy, family history of cardiovascular diseases, smoking habits, gestational diabetes diagnosed before pre-eclampsia, body mass index and labour complications will be considered a priori as potential confounders of the association between pre-eclampsia and postpartum cardiovascular impairment.Ethics and dissemination This study was approved by the Comité Nacional de Ética em Pesquisa na Saúde, Guinea-Bissau (008/CNES/INASA/2023), and participants provide written informed consent. Results will be disseminated among the scientific community and the public.https://bmjopen.bmj.com/content/14/12/e091882.full |
| spellingShingle | Albertino Damasceno Amabelia Rodrigues Nuno Lunet Ruben Turé Eunice Barai Almame Cissé Gabriel Sanca Tida Iafa Waldir Jalo Bubacar Embalo Marcos Dju Vasco Iala Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study BMJ Open |
| title | Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study |
| title_full | Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study |
| title_fullStr | Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study |
| title_full_unstemmed | Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study |
| title_short | Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study |
| title_sort | pre eclampsia as a predictor of early onset cardiovascular impairment among young women preecardia study protocol for a prospective cohort study |
| url | https://bmjopen.bmj.com/content/14/12/e091882.full |
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