Current approaches to osteoarthritis phenotyping
Osteoarthritis (OA) is currently considered as a heterogeneous disease that can be represented by different subtypes. It is the study of OA phenotypes that is one of the strategic areas for the development of researches on this nosological entity, which will further allow a personified approach to p...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2019-05-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/904 |
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| _version_ | 1849691586066120704 |
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| author | A. M. Lila L. I. Alekseeva K. A. Telyshev |
| author_facet | A. M. Lila L. I. Alekseeva K. A. Telyshev |
| author_sort | A. M. Lila |
| collection | DOAJ |
| description | Osteoarthritis (OA) is currently considered as a heterogeneous disease that can be represented by different subtypes. It is the study of OA phenotypes that is one of the strategic areas for the development of researches on this nosological entity, which will further allow a personified approach to patient therapy and ensure the rational use of financial resources of health care.The paper describes in detail the current researches on this issue. It discusses attempts to identify different OA types according to demographic data (age, race, gender, etc.), comorbidity (including depression), nature of pain (intensity, pathophysiological mechanisms of its development), biochemical markers, genetic and biomechanical predictors, hormonal status in patients, and structural changes detected by ultrasound, magnetic resonance imaging, and computed tomography, etc. |
| format | Article |
| id | doaj-art-039d499fb6d24e8e8c205a11b55f9832 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2019-05-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-039d499fb6d24e8e8c205a11b55f98322025-08-20T03:20:59ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2019-05-011324810.14412/1996-7012-2019-2-4-82161Current approaches to osteoarthritis phenotypingA. M. Lila0L. I. Alekseeva1K. A. Telyshev2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyOsteoarthritis (OA) is currently considered as a heterogeneous disease that can be represented by different subtypes. It is the study of OA phenotypes that is one of the strategic areas for the development of researches on this nosological entity, which will further allow a personified approach to patient therapy and ensure the rational use of financial resources of health care.The paper describes in detail the current researches on this issue. It discusses attempts to identify different OA types according to demographic data (age, race, gender, etc.), comorbidity (including depression), nature of pain (intensity, pathophysiological mechanisms of its development), biochemical markers, genetic and biomechanical predictors, hormonal status in patients, and structural changes detected by ultrasound, magnetic resonance imaging, and computed tomography, etc.https://mrj.ima-press.net/mrj/article/view/904osteoarthritisapproaches to phenotypingphenotypespersonalized therapy |
| spellingShingle | A. M. Lila L. I. Alekseeva K. A. Telyshev Current approaches to osteoarthritis phenotyping Современная ревматология osteoarthritis approaches to phenotyping phenotypes personalized therapy |
| title | Current approaches to osteoarthritis phenotyping |
| title_full | Current approaches to osteoarthritis phenotyping |
| title_fullStr | Current approaches to osteoarthritis phenotyping |
| title_full_unstemmed | Current approaches to osteoarthritis phenotyping |
| title_short | Current approaches to osteoarthritis phenotyping |
| title_sort | current approaches to osteoarthritis phenotyping |
| topic | osteoarthritis approaches to phenotyping phenotypes personalized therapy |
| url | https://mrj.ima-press.net/mrj/article/view/904 |
| work_keys_str_mv | AT amlila currentapproachestoosteoarthritisphenotyping AT lialekseeva currentapproachestoosteoarthritisphenotyping AT katelyshev currentapproachestoosteoarthritisphenotyping |