Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality

Abstract The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium’s superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation...

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Main Authors: Mustafa Tunalı, Esra Ercan, Suat Pat, Emrah Sarıca, Aysel Güven Bağla, Nilüfer Aytürk, Duygu Sıddıkoğlu, Vildan Bilgin
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Journal of Materials Science: Materials in Medicine
Online Access:https://doi.org/10.1007/s10856-024-06838-3
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author Mustafa Tunalı
Esra Ercan
Suat Pat
Emrah Sarıca
Aysel Güven Bağla
Nilüfer Aytürk
Duygu Sıddıkoğlu
Vildan Bilgin
author_facet Mustafa Tunalı
Esra Ercan
Suat Pat
Emrah Sarıca
Aysel Güven Bağla
Nilüfer Aytürk
Duygu Sıddıkoğlu
Vildan Bilgin
author_sort Mustafa Tunalı
collection DOAJ
description Abstract The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium’s superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface’s debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine. Graphical Abstract
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spelling doaj-art-03583ac373d84daa8a73069ead38ea692024-12-22T12:10:42ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382024-11-013511910.1007/s10856-024-06838-3Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) qualityMustafa Tunalı0Esra Ercan1Suat Pat2Emrah Sarıca3Aysel Güven Bağla4Nilüfer Aytürk5Duygu Sıddıkoğlu6Vildan Bilgin7Department of Periodontology, Faculty of Dentistry, Canakkale Onsekiz Mart UniversityDepartment of Periodontology, Faculty of Dentistry, Canakkale Onsekiz Mart UniversityDepartment of Physics, Faculty of Science, Eskişehir Osmangazi UniversityDepartment of Electrical and Electronics Engineering, Faculty of Engineering, Baskent UniversityDepartment of Histology and Embryology, Faculty of Medicine, Canakkale Onsekiz Mart UniversityDepartment of Histology and Embryology, Faculty of Medicine, Canakkale Onsekiz Mart UniversityDepartment of Biostatistics, Faculty of Medicine, Canakkale Onsekiz Mart UniversityDepartment of Physics, Faculty of Science, Canakkale Onsekiz Mart UniversityAbstract The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium’s superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface’s debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine. Graphical Abstracthttps://doi.org/10.1007/s10856-024-06838-3
spellingShingle Mustafa Tunalı
Esra Ercan
Suat Pat
Emrah Sarıca
Aysel Güven Bağla
Nilüfer Aytürk
Duygu Sıddıkoğlu
Vildan Bilgin
Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
Journal of Materials Science: Materials in Medicine
title Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
title_full Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
title_fullStr Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
title_full_unstemmed Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
title_short Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality
title_sort nano titanium coating on glass surface to improve platelet rich fibrin prf quality
url https://doi.org/10.1007/s10856-024-06838-3
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