Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome

Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome

Abstract Background Adults with Down syndrome (DS) have a 90% lifetime risk for Alzheimer’s disease (AD), with neurobiological pathology present decades prior to dementia onset. The profile and timing of cognitive decline in DS is well-documented. However, there is a small body of research on whethe...

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Main Authors: Melissa R. Jenkins, Jamie C. Peven, Lauren Kubic, Benjamin L. Handen, Sharon J. Krinsky-McHale, Christy L. Hom, Alice Lee, Dana L. Tudorascu, Max McLachlan, Matthew Zammit, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Ira Lott, Annie Cohen, Beau M. Ances, H. Diana Rosas, Florence Lai, Shahid H. Zaman, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Sigan L. Hartley, the Alzheimer Biomarker Consortium - Down syndrome
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Down syndrome
Alzheimer’s disease
Amyloid
Tau
Psychiatric symptoms
Online Access:https://doi.org/10.1186/s11689-025-09604-w
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