Validation of a semi-automated method to quantify lesion volume changes in multiple sclerosis on 2D proton-density-weighted scans based on image subtraction by Rozemarijn M. Mattiesing, Serena Stel, Alysha S. Mangroe, Iman Brouwer, Adriaan Versteeg, Ronald A. van Schijndel, Bernard M.J. Uitdehaag, Frederik Barkhof, Hugo Vrenken, Joost P.A. Kuijer

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